12th Vitreoretinal Symposium Frankfurt – Marburg 2009

Scientific programm: Abstract

2nd scientific session: (Core) PPV

8. NSAID for Retinal and Anterior Segment Diseases

William Aldred (Pensacola)

Purpose: To review current NSAID options and practice in ocular disease and retinal edema.
Methods: Literature review and basic science presentation.
Results: A brief history and overview of NSAIDs in ophthalmology, comparing molecular structure to proposed mechanisms of pharmacologic action is given. Methods of comparing potency are discussed. A critical review of Phase III trial conclusions is presented. Theories of efficacy and clinical utility for the leading agents are presented. Emphasis is placed upon therapeutic utility for Ketorolac, Nepafenac and Bromfenac. Conflicting Claims for these agents are evaluated. Discussion of the systemic use of NSAIDS in eye disease and surgery is also presented.
Conclusions: Options are expanding for the use of topical NSAIDs in anterior segment and retinal disease. This presentation will hopefully aid the clinician in selecting the most appropriate NSAID for his particular clinical indication.